mRNA capping rate detection Pretreatment kit

The capping rate is an important quality attribute indicator for various mRNA drugs, including mRNA vaccines, and it is a necessary verification data for the application of mRNA products. At present, the determination of capping rate is mainly carried out by liquid chromatography-mass spectrometry. There is a difference in molecular weight between capped mRNA and uncapped mRNA in the order of hundreds. Compared with the molecular weight of intact mRNA in the hundreds of thousands, it is difficult to precisely analyze the difference between capped and uncapped samples. Therefore, the analysis of the capping rate first requires processing long mRNA fragments into small ones, transforming the differences of the hundreds of thousands into those of the hundreds of thousands.

Item No. : BP-05-10

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